Marfan Syndrome-a disorder of connective tissue, resulting in abnormally long and thin digits and also frequently in optical and cardiovascular defects. Disorders of connective tissue affect the skeletal system, cardiovascular system, eyes, and skin. Marfan syndrome is caused by defects in gene called fibrillin-1. Fibrillin-1 plays an important role as the building block for connective tissues in the body. The gene defect also causes too much growth of long bones of the body. This causes the tall height and long arms and legs seen in people with this syndrome. How this overgrowth happens is not well understood. In most cases, Marfan syndrome is inherited, which means it is passed down through families. However, up to 30% of patients have no family history, which is called "sporadic." In sporadic cases, the syndrome is believed to be caused by a new gene change.
http://www.youtube.com/watch?v=ab_B0lZqq6M
info: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001455/#adam_000418.disease.causes
http://www.youtube.com/watch?v=ab_B0lZqq6M
info: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001455/#adam_000418.disease.causes